Companies face significant challenges impacting their strategies and operations in dynamic markets, primarily from political, technological, and regulatory sources. In Europe, regulatory developments like the Network Information Security (NIS) Directive 2.0 and the Digital Operational Resilience Act (DORA) intensify pressures. Integrating these laws into business operations involves managing cross-market dependencies, operating in multiple countries, navigating political uncertainties, avoiding high compliance costs, and coping with frequent regulatory changes. To ensure positive regulatory audit outcomes, companies should use a framework that includes gap analysis, audit preparation and execution, remediation, and robust project management. Success for project and program management depends on methodological competence, relevant tools, and expert access.